The synthesis and diuretic activity were reported of a series of N1-(4-chloro-3-sulfamoylbenzamide)-N4-alkylpiperazines, 2-methyl- and cis-2,6-dimethyl substituted, structurally related to clopamide, as well as of two N4-alkyl-N1-(4-chloro-3-sulfamoylbenzoyl)-2-methyl-1,2,3, 4-tetrahydroquinoxalines. In the piperazine series the presence of methyl group in position 2 and 6 of the piperazinic ring was found to increase the diuretic potency of the C-unmethylated compound.

C-alkylpiperazines. XII. Synthesis and diuretic activity of compounds structurally related to clopamide / Landriani L; Barlocco D; Cignarella G; Curzu MM; Anania V; Desole M.S.. - In: IL FARMACO. EDIZIONE SCIENTIFICA. - ISSN 0430-0920. - 42:3(1987), pp. 191-204.

C-alkylpiperazines. XII. Synthesis and diuretic activity of compounds structurally related to clopamide

DESOLE, Maria Speranza
1987

Abstract

The synthesis and diuretic activity were reported of a series of N1-(4-chloro-3-sulfamoylbenzamide)-N4-alkylpiperazines, 2-methyl- and cis-2,6-dimethyl substituted, structurally related to clopamide, as well as of two N4-alkyl-N1-(4-chloro-3-sulfamoylbenzoyl)-2-methyl-1,2,3, 4-tetrahydroquinoxalines. In the piperazine series the presence of methyl group in position 2 and 6 of the piperazinic ring was found to increase the diuretic potency of the C-unmethylated compound.
C-alkylpiperazines. XII. Synthesis and diuretic activity of compounds structurally related to clopamide / Landriani L; Barlocco D; Cignarella G; Curzu MM; Anania V; Desole M.S.. - In: IL FARMACO. EDIZIONE SCIENTIFICA. - ISSN 0430-0920. - 42:3(1987), pp. 191-204.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11388/139595
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