Combination therapywithtwoormoreanalgesicsiswidelyusedforconditionsassociatedwithmod- eratetoseverepain.Combinationsofdiverseanalgesicswithdifferentmodesofactioncanimprovethe risk-benefit ratioofanalgesictreatments.Theaimofthisstudyistoevaluatetheantinociceptiveeffectof tapentadol (TAP)and flupirtine (FLP),whenadministeredseparatelyorincombination,aswellastheir synergistic interactionintheorofacialformalintestinrats.Afteri.p.injectionofTAPatdifferentdoses(2, 5, 10and15mg/kg),thebiphasicnociceptivebehaviorwasreducedinadose-dependentmannerinboth phase IandII.Conversely,i.p.injectionofFLPatdifferentdoses(0.6,1.6,3.3,6.6,16.6and22.2mg/kg) induced adose-dependentantinociceptiveeffectinphaseIIonly.TAPwasfoundtobemoreeffective than FLP.TheinteractionbetweenTAPandFLPwassynergisticinphaseIIwithaninteractionindex(γ) of 0.5070.24. ThedatareportedinthisstudyindicatethatFLPenhancestheantinociceptiveeffectofTAP and thisdrugcombinationmightbepotentiallyusefulinthetreatmentofchronicpain
Synergistic interaction between tapentadol and flupirtine in the rat orafacial formalin test / Lee, Hk; DE VITO, Virginia; Giorgi, M; Yun, H.. - In: EUROPEAN JOURNAL OF PHARMACOLOGY. - ISSN 0014-2999. - 762:(2015), pp. 350-356.
Synergistic interaction between tapentadol and flupirtine in the rat orafacial formalin test
DE VITO, Virginia;
2015-01-01
Abstract
Combination therapywithtwoormoreanalgesicsiswidelyusedforconditionsassociatedwithmod- eratetoseverepain.Combinationsofdiverseanalgesicswithdifferentmodesofactioncanimprovethe risk-benefit ratioofanalgesictreatments.Theaimofthisstudyistoevaluatetheantinociceptiveeffectof tapentadol (TAP)and flupirtine (FLP),whenadministeredseparatelyorincombination,aswellastheir synergistic interactionintheorofacialformalintestinrats.Afteri.p.injectionofTAPatdifferentdoses(2, 5, 10and15mg/kg),thebiphasicnociceptivebehaviorwasreducedinadose-dependentmannerinboth phase IandII.Conversely,i.p.injectionofFLPatdifferentdoses(0.6,1.6,3.3,6.6,16.6and22.2mg/kg) induced adose-dependentantinociceptiveeffectinphaseIIonly.TAPwasfoundtobemoreeffective than FLP.TheinteractionbetweenTAPandFLPwassynergisticinphaseIIwithaninteractionindex(γ) of 0.5070.24. ThedatareportedinthisstudyindicatethatFLPenhancestheantinociceptiveeffectofTAP and thisdrugcombinationmightbepotentiallyusefulinthetreatmentofchronicpainI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
