Combination therapywithtwoormoreanalgesicsiswidelyusedforconditionsassociatedwithmod- eratetoseverepain.Combinationsofdiverseanalgesicswithdifferentmodesofactioncanimprovethe risk-benefit ratioofanalgesictreatments.Theaimofthisstudyistoevaluatetheantinociceptiveeffectof tapentadol (TAP)and flupirtine (FLP),whenadministeredseparatelyorincombination,aswellastheir synergistic interactionintheorofacialformalintestinrats.Afteri.p.injectionofTAPatdifferentdoses(2, 5, 10and15mg/kg),thebiphasicnociceptivebehaviorwasreducedinadose-dependentmannerinboth phase IandII.Conversely,i.p.injectionofFLPatdifferentdoses(0.6,1.6,3.3,6.6,16.6and22.2mg/kg) induced adose-dependentantinociceptiveeffectinphaseIIonly.TAPwasfoundtobemoreeffective than FLP.TheinteractionbetweenTAPandFLPwassynergisticinphaseIIwithaninteractionindex(γ) of 0.5070.24. ThedatareportedinthisstudyindicatethatFLPenhancestheantinociceptiveeffectofTAP and thisdrugcombinationmightbepotentiallyusefulinthetreatmentofchronicpain

Synergistic interaction between tapentadol and flupirtine in the rat orafacial formalin test / Lee, Hk; DE VITO, Virginia; Giorgi, M; Yun, H.. - In: EUROPEAN JOURNAL OF PHARMACOLOGY. - ISSN 0014-2999. - 762:(2015), pp. 350-356.

Synergistic interaction between tapentadol and flupirtine in the rat orafacial formalin test

DE VITO, Virginia;
2015

Abstract

Combination therapywithtwoormoreanalgesicsiswidelyusedforconditionsassociatedwithmod- eratetoseverepain.Combinationsofdiverseanalgesicswithdifferentmodesofactioncanimprovethe risk-benefit ratioofanalgesictreatments.Theaimofthisstudyistoevaluatetheantinociceptiveeffectof tapentadol (TAP)and flupirtine (FLP),whenadministeredseparatelyorincombination,aswellastheir synergistic interactionintheorofacialformalintestinrats.Afteri.p.injectionofTAPatdifferentdoses(2, 5, 10and15mg/kg),thebiphasicnociceptivebehaviorwasreducedinadose-dependentmannerinboth phase IandII.Conversely,i.p.injectionofFLPatdifferentdoses(0.6,1.6,3.3,6.6,16.6and22.2mg/kg) induced adose-dependentantinociceptiveeffectinphaseIIonly.TAPwasfoundtobemoreeffective than FLP.TheinteractionbetweenTAPandFLPwassynergisticinphaseIIwithaninteractionindex(γ) of 0.5070.24. ThedatareportedinthisstudyindicatethatFLPenhancestheantinociceptiveeffectofTAP and thisdrugcombinationmightbepotentiallyusefulinthetreatmentofchronicpain
Synergistic interaction between tapentadol and flupirtine in the rat orafacial formalin test / Lee, Hk; DE VITO, Virginia; Giorgi, M; Yun, H.. - In: EUROPEAN JOURNAL OF PHARMACOLOGY. - ISSN 0014-2999. - 762:(2015), pp. 350-356.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11388/138081
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