Carcinogenicity of certain nickel compounds has been confirmed by the combination of epidemiological evidence in humans and carcinogenesis bioassays in animals. We have previously reported that nickel is a potent suppressor of histone H4 acetylation in both yeast and mammalian cells. We have recently carried out a study on the coordination ability of Ni(II) to the N-terminal tail of histone H4 by the use of multidimensional NMR techniques (1D, 2D TOCSY and NOESY spectra) [I]. The data thus collected allowed us to calculate a structural model for the square planar complex formed by the Ni(II) ion and ow peptide, pointing out the important structural changes induced by nickel coordination on the peptide.

Structural changes induced by nickel binding to the N-tail of Histone H4: an NMR study / Zoroddu, Maria Antonietta; Peana, Massimiliano Francesco; Medici, Serenella. - (2006), pp. 392-392. (Intervento presentato al convegno “1st European Chemistry Congress” tenutosi a Budapest, Ungheria nel 27-31 Agosto 2006).

Structural changes induced by nickel binding to the N-tail of Histone H4: an NMR study

ZORODDU, Maria Antonietta;PEANA, Massimiliano Francesco;MEDICI, Serenella
2006-01-01

Abstract

Carcinogenicity of certain nickel compounds has been confirmed by the combination of epidemiological evidence in humans and carcinogenesis bioassays in animals. We have previously reported that nickel is a potent suppressor of histone H4 acetylation in both yeast and mammalian cells. We have recently carried out a study on the coordination ability of Ni(II) to the N-terminal tail of histone H4 by the use of multidimensional NMR techniques (1D, 2D TOCSY and NOESY spectra) [I]. The data thus collected allowed us to calculate a structural model for the square planar complex formed by the Ni(II) ion and ow peptide, pointing out the important structural changes induced by nickel coordination on the peptide.
2006
963-9319-61-9
Structural changes induced by nickel binding to the N-tail of Histone H4: an NMR study / Zoroddu, Maria Antonietta; Peana, Massimiliano Francesco; Medici, Serenella. - (2006), pp. 392-392. (Intervento presentato al convegno “1st European Chemistry Congress” tenutosi a Budapest, Ungheria nel 27-31 Agosto 2006).
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11388/72813
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