Alcohol and tobacco: is acetaldehyde the reinforcing bridge? (symposium organizer & chair)

Alcohol and nicotine, in the form of tobacco smoke are frequently used drugs of abuse, often taken together. The modalities by which nicotine or other components in tobacco smoke can affect alcohol consumption have been largely investigated. A crucial role in tobacco smoke effects seems to be played by acetaldehyde, one of its more abundant component. Acetaldehyde is also ethanol first metabolite, and is able to mediate some of the central effects induced by alcohol. This symposium origins then from the idea that acetaldehyde may act as a priming factor when taken in tobacco smoke during adolescence, and may be able to enhance alcohol consumption in adulthood. Some of the most active neuroscientists in the field will try to elucidate and highlight the role of acetaldehyde as a substance of abuse and its potential as a possible pharmacological target. In particular Prof. Peana will talk on acetaldehyde as a mediator of alcohol central effects; Prof. Cannizzaro will lecture on acetaldehyde addictive properties; Prof. Chiamulera will lecture on the role of acetaldehyde on nicotine and tobacco dependence, Prof. Correa will lecture on acetaldehyde central metabolism.