Continuous Flow Chemistry Techniques in the Synthesis of Strained Carbo- and Heterocyclic Compounds

In the pursuit of advancing organic chemistry, this doctoral thesis presents an innovative approach that integrates process chemistry with flow chemistry to synthesize and functionalize strained carbocycles. This approach challenges traditional synthetic paradigms and redefines efficiency, sustainability, and scalability in chemical synthesis. Recognizing the limitations of conventional batch reactions, such as scalability constraints and significant waste production, this research transitions to flow chemistry systems to enhance reaction efficiency, reduce waste, and improve sustainability. The core of this thesis lies in optimizing traditional synthetic methods into more productive and eco-friendly flow chemistry processes. This transformation leverages the advantages of flow chemistry, including superior reaction control, enhanced safety, and efficient waste management. A key highlight is the development of a multi-step reaction sequence for synthesizing valuable building blocks, starting with the conversion of alkynes to diketones, followed by photocyclization, and culminating in the formation of cyclopropyl-thio-ketones, cyclopropylamines, and γ-lactones through various nucleophilic additions. The thesis also addresses the challenges of stability and scalability in flow chemistry setups, providing insights into transitioning from batch to flow processes. Through detailed optimization and creative problem-solving, this research establishes a foundation for future advancements in process chemistry, emphasizing its role in steering organic synthesis towards more sustainable and productive practices. By facilitating the large-scale production of complex organic compounds with minimal environmental impact, this thesis contributes to a more sustainable future in chemical manufacturing. The innovative use of flow chemistry techniques presented in this research marks a significant leap forward in organic synthesis, heralding a new era of greener, safer, and more efficient chemical production.