8 Tesi di dottorato

8 Tesi di dottorato: [1486] Home page macrotipologia

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8.1 Tesi di dottorato 212
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Part I: Analysis of the Biological Activity of Acidic Polysaccharides Extracted from Marine Organisms Sarcotragus spinosulus and Holothuria tubulosa on Tumor Cell Lines MCF-7 and MDA-MB-23 Part II: Role of LRRK2 in Parkinson's Disease: Insights into Vesicular Trafficking and Neuroinflammation

In recent years, bioactive compounds extracted from primitive marine organisms have gained attention for their potential anticancer properties. In this study, acidic polysaccharides (APs) from Holothuria tubulosa and Sarcotragus spinosulus were investigated for their effects on MDA-MB-231 and MCF-7 breast cancer cells. Holothuria-derived APs (Ht1, Ht2) exhibited anticancer potential, with Ht1 reducing cell viability and migration while promoting an epithelial-like phenotype in MDA-MB-231 cell...

Exploring Microgravity’s Dual Impact: Insights into Arthrospira platensis Bioactivity and Parkinson’s Disease Pathology

Microgravity, or weightlessness, poses significant challenges for biological systems in space, necessitating terrestrial models to simulate and study its effects. The random positioning machine (RPM) offers a unique platform to recreate microgravity-like conditions on Earth. This thesis investigates the dual impact of microgravity on Arthrospira platensis, a cyanobacterium, and on cellular models of Parkinson’s disease (PD), a neurodegenerative disorder. The research focuses on the biochemica...

Transcriptomic Profiling for Prognostic Model Construction and Biomarker Discovery in Colorectal Cancer

Colorectal cancer (CRC), a leading global malignancy with high morbidity and mortality, urgently requires improved predictive models and biomarkers to address its heterogeneous progression and suboptimal survival outcomes. While advances in screening have been made, the five-year survival rate remains low—particularly for advanced-stage patients—highlighting the need for precision-driven strategies. This study leverages next-generation sequencing (NGS) and bioinformatics to systematically ana...

Movement ecology in upper vertebrates

Movement ecology examines the spatial and temporal dynamics of organisms' movements, shaped by intrinsic and environmental factors. Studying the movement patterns of upper vertebrates is crucial for understanding ecosystem processes, conservation, and managing human-wildlife conflicts. The recent expansion of upper vertebrate populations in Italy, driven by conservation policies and land-use changes, underscores the importance of understanding these movement patterns in anthropogenic landscap...

Urban Free Zones: Economic Recovery and Territorial Development through Tax-Free Zones and a strategic application of Territorial Marketing.

This doctoral thesis presents a study on Urban Free Zones (UFZs), a type of tax-free area aimed at business. Established in France and Italy, UFZs aim to facilitate economic recovery in degraded urban areas by attracting enterprises through tax exemptions. Previous research has focused on all French UFZs, while studies on the Italian context remain limited to a regional scope. Therefore, this research aims to provide a detailed understanding of all Urban Free Zones established in Italy and, c...

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