Beyond Conventional Routes: Mechanochemical Transformations in Organic Synthesis for Sustainable Chemistry

This thesis is aimed at providing a novel perspective about the contribution of mechanochemistry in the process chemistry’s panorama. Leafing through the chapters of the present dissertation, one will delve into some information about historical background of organic chemistry and its interaction with this contemporary enabling technology and process sustainability. This will serve as the necessary background for introducing the course I navigated in assembling my thesis, which was directed towards the demonstration and subsequent integration of diverse molecular architectures and multi-step processes within mechanochemistry, with some recalls to industrial scalability. The synthesis of indoles constituted the first step for building molecular complexity, while formamides, isocyanides and sulfonamides served as the direct nexus to process chemistry and sustainable synthetic plans. Lastly, the investigation of catalytic hydrogenation through ball milling paved the way to laboratory and potential industrial scale-up assessment.

This thesis is aimed at providing a novel perspective about the contribution of mechanochemistry in the process chemistry’s panorama. Leafing through the chapters of the present dissertation, one will delve into some information about historical background of organic chemistry and its interaction with this contemporary enabling technology and process sustainability. This will serve as the necessary background for introducing the course I navigated in assembling my thesis, which was directed towards the demonstration and subsequent integration of diverse molecular architectures and multi-step processes within mechanochemistry, with some recalls to industrial scalability. The synthesis of indoles constituted the first step for building molecular complexity, while formamides, isocyanides and sulfonamides served as the direct nexus to process chemistry and sustainable synthetic plans. Lastly, the investigation of catalytic hydrogenation through ball milling paved the way to laboratory and potential industrial scale-up assessmen