The carcinogenicity of nickel compounds has been confirmed and corroborated by numerous epidemiological studies in humans and carcinogenesis bioassays in animals. We also found that an excellent tumour marker recently discovered and specifically induced by nickel, Cap43 protein, has a new mono-histidinic motif consisting of ten amino acids TRSRSHTSEG repeated three times in the C-terminus which is able to bind several metal ions in a cooperative way.
Molecular mechanisms of nickel carcinogenesis: nickel binding to histone H4 and Cap43 protein / Zoroddu, Maria Antonietta; Peana, Massimiliano Francesco; Medici, Serenella. - (2005), pp. 70-70. (Intervento presentato al convegno Inquinamento da metalli pesanti: la biodisponibilità: 3. Conferenza organizzativa).
Molecular mechanisms of nickel carcinogenesis: nickel binding to histone H4 and Cap43 protein
Zoroddu, Maria Antonietta;Peana, Massimiliano Francesco;Medici, Serenella
2005-01-01
Abstract
The carcinogenicity of nickel compounds has been confirmed and corroborated by numerous epidemiological studies in humans and carcinogenesis bioassays in animals. We also found that an excellent tumour marker recently discovered and specifically induced by nickel, Cap43 protein, has a new mono-histidinic motif consisting of ten amino acids TRSRSHTSEG repeated three times in the C-terminus which is able to bind several metal ions in a cooperative way.| File | Dimensione | Formato | |
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