Sintesi ed applicazione in catalisi asimmetrica di derivati piridinici chiarli e non: fenantroline amino-piridine, amino-chinoline e fosfino-piridine

This thesis mainly concerns two important areas of Organic Chemistry: synthesis and catalysis. In particular our aim was to synthesize new pyridine-based ligands and to prove their ability in catalytic asymmetric reactions. Moreover we explored alternative approaches for the synthesis of molecules of interest in different fields of Chemistry. We can briefly summarize our results as follows:1. The achievement of a new procedure to obtain optically active 1- substituted-1-(pyridin-2-yl)methylamines by diastereoselective reduction of enantiopure ketimines.2. The synthesis of new pincer CNN ligands based on the benzo[h]quinoline framework and catalytic applications of their Ru- and Os-complexes.3. The development of alternative approaches to the synthesis of 1,10- phenanthrolines and to compounds that are key-intermediates in the synthesis of the 1,10-phenanthroline core.4. The synthesis of a new pyridine-based N-P ligand derived from optically active camphor and some preliminary results about its activity in catalytic reactions.