Aim:A new electromagnetic technology, aimed to the cancer diagnosis, as available in the last years literature, could be a promising non invasive method for detection of colon diseases including cancer . The encouraging published data, regarding specificity and sensitivity of the Nonlinear Resonance Interaction capabilities to analyze some peculiar electromagnetic properties of cancerousvs. normal tissues, related to various clinical trials on prostate, bladder, breast, thyroid, rectum cancer calls for further diagnostic application trials.Methods:This was a single-centre pilot study. Before colonoscopy, each patient was screened with the TRIMprobe for colonic lesions by an operator in blind. The TRIMprob was moved over the surface of the abdomen area, with the patient standing, normally dressed, between the operator and the system receiver. The signal variation of 3 spectral lines, for 465-MHz, 930-MHz, and 1395-MHz frequencies were recorded. The different anisotropy reveals abnormal tissues. Biopsies collected during colonoscopy were used as Gold Standard. Statistical analysis was performed by chi-squared test.Results:A total of 91 consecutive patients (mean age: 56 years) undergoing colonoscopy were enrolled. The TRIMprob was able to detect colonic neoplasms in all patients (5/5). Sensitivity, specificity and accuracy of the Bioscanner compared to the histological examination were 100 %, 100 %, and 100 %, respectively. The concordance of the results of the two tests was highly significant (p < 0.0001).Conclusion:Although these preliminary results need to be verified and extended in routine clinical setting, simplicity and the high diagnostic yield of the TRIMprob suggest that this method should be suitable as a first-level screening tool in detecting colorectal lesions.

L'Accuratezza diagnostica del bioscanner TRIMPROB: uno strumento non invasivo per la diagnosi delle lesioni pre-neoplastiche del colon: uno studio prospettico in doppio cieco(2014 Feb 24).

L'Accuratezza diagnostica del bioscanner TRIMPROB: uno strumento non invasivo per la diagnosi delle lesioni pre-neoplastiche del colon: uno studio prospettico in doppio cieco

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2014-02-24

Abstract

Aim:A new electromagnetic technology, aimed to the cancer diagnosis, as available in the last years literature, could be a promising non invasive method for detection of colon diseases including cancer . The encouraging published data, regarding specificity and sensitivity of the Nonlinear Resonance Interaction capabilities to analyze some peculiar electromagnetic properties of cancerousvs. normal tissues, related to various clinical trials on prostate, bladder, breast, thyroid, rectum cancer calls for further diagnostic application trials.Methods:This was a single-centre pilot study. Before colonoscopy, each patient was screened with the TRIMprobe for colonic lesions by an operator in blind. The TRIMprob was moved over the surface of the abdomen area, with the patient standing, normally dressed, between the operator and the system receiver. The signal variation of 3 spectral lines, for 465-MHz, 930-MHz, and 1395-MHz frequencies were recorded. The different anisotropy reveals abnormal tissues. Biopsies collected during colonoscopy were used as Gold Standard. Statistical analysis was performed by chi-squared test.Results:A total of 91 consecutive patients (mean age: 56 years) undergoing colonoscopy were enrolled. The TRIMprob was able to detect colonic neoplasms in all patients (5/5). Sensitivity, specificity and accuracy of the Bioscanner compared to the histological examination were 100 %, 100 %, and 100 %, respectively. The concordance of the results of the two tests was highly significant (p < 0.0001).Conclusion:Although these preliminary results need to be verified and extended in routine clinical setting, simplicity and the high diagnostic yield of the TRIMprob suggest that this method should be suitable as a first-level screening tool in detecting colorectal lesions.
TRIMPROB; lesioni preneoplastiche; colon
Tufano, Onofrio Marcello
L'Accuratezza diagnostica del bioscanner TRIMPROB: uno strumento non invasivo per la diagnosi delle lesioni pre-neoplastiche del colon: uno studio prospettico in doppio cieco(2014 Feb 24).
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11388/250824
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