Metodi di screening, conferma e separazione enantiomerica di nuovi designer drugs amfetamino-simili

Amphetamine designer drugs are central nervous system stimulants widely diffused worldwide in illegal markets. Their identification is often difficult, because of the high structural variety of new compounds. Monitoring of drugs of abuse in biological fluids is successfully used for clinical and forensic applications.In this work a method for identify and quantify 3,4-methylenedioxy-N-isopropylamphetamine (MDIP), 3,4-methylenedioxy-N-cyclopropylmethylamphetamine (MDCPM), 3,4-methylenedioxy-N-benzylamphetamine (MDBZ) and 3,4-methylenedioxy-N-ethylamphetamine (MDE) in urine, and a method for identify and quantify 4-bromo-2,5,beta-trimethoxyphenethylamine (BOB), 4-methyl-2,5,beta-trimethoxyphenethylamine (BOD), 3,4-methylenedioxy-beta-methoxyphenethylamine (BOH) and 4-methyl-2,5-dimethoxy-beta-hydroxyphenethylamine (BOHD) in plasma are described.In addition, the cross-reactivity profiles of 41 new amphetamines to 6 commonly used screening tests for urine and oral fluid are reported.Furthermore an easy-to-prepare chiral CE method for the enantiomeric separation of 13 new amphetamine-like designer drugs using cyclodextrins as chiral selectors has been developed.