Studio di alcuni oli essenziali nella pratica clinica

During the Ph.D. period, mastery of several traditional microbiology techniques, such as bacteriology and cytology, and molecular techniques was acquired, with application on randomized clinical trials.The research activity has focused mainly onin vitroantibacterial, antioxidant and cytotoxic activity with subsequent application of some essential oils in vivo on animals and on humans.Considering the results obtained, it is clear thatThymus vulgaris - red thyme geraniol selandL. grossooils have shown good antimicrobial activity, compared toL. angustifoliaandL. sumianon multi-drug clinical strains ofP. aeruginosa. WhileL. angustifolia Millerpresented a cytotoxic action on CaCo-2 cells (Colon-carcinoma Carcinoma Cells) probably due to the action of terpenes.The oleolites ofHelichrysum microphyllum Cambess. subsp. tyrrhenicum Bacch.,Brullo & GiussoandHypericum perforatum subsp. Angustifoliumwere tested against 30 strains ofCandida spp.: the oleolite ofH. microphyllumshowed greater antifungal activity compared toH. perforatum.Finally, the antifungal action ofMirtus communiswas studied against 86 strains ofMalassezia spp.: the obtained data showed a remarkable activity againstM. furfurandM. sympodialis.Furthermore, an in vivo study was performed and we present here the preliminary data.The topic developed is part of a research area aimed at the use of essential oils with antibacterial activity in the problem of drug resistance.