Aspetti radiomici del tumore mammario: studio di associazione trasignatureradiomica ed istotipo

Aimof this study is to assess the role of radiomics in breast cancer, focusing on its ability to predict histological phenotypes.Methods: It was carried out a retrospective study including all breast cancer patients who referred to the Diagnostic Imaging 2 Institute to perform a breast MRI prior to surgery. Histologic confirmation on surgical specimen was obtained in all patients.Results: All patients underwent a high-field (1,5 T) breast MRI (T2-weight sequences with fat suppression, T1-weight sequences and T1 after IV contrast administration). MRI enhanced sequences were contoured and first-order radiomics features were extracted through dedicated software, called 3DSlicer. Taking into account the current literature, three features were selected: entropy, 90° percentile and skewness. The association between the selected features and the histological patterns were explored.Conclusion: A possible integration of quantitative data, provided by a radiomics analysis, with clinical and histological data could enable clinicians to provide an early and accurate diagnosis as well as personalized treatments for breast cancer patients. Current limitations of a routinely application of radiomics seem both the limited knowledge among physicians of this quantitative radiological tool and the lack of standardized systems of feature extraction and data sharing.