Objective: To exame sensitivity of brainbstem relflex (BSRs) and to correlate BSRs with multimodal evoked potentials (m EPs) and brain MRI lesion burden in relapsing-remitting multiple sclerosis patrient (RRMS). Methods: sixty RRMS patients ( age 33.3+/- 8.3, range 20-50, desease duration 8.2+/- 6.4 yrs, EDSS score 1.8+/-1.1) Underwent visual, acoustic, upper and lower somatosensory EP recordings (rispectively VEP, ABR, median SEP-mSEP and tibial SEP-tSEP9 and brain MRI. BSRs of interest were. the vestibulo-collic (VCR), trigemino-cervical (TCR), vestibulomasseteric (VMR) and acoustic- masseteric (AMR) reflexes. Neurological examination was rated according to the EDSS scale, mPE, BSRs, brain MRI and EDSS data wer quantified according to a conventional score. Results: EP abnormalities were recorded in 84.5% of patients distributed as follows: VEP 43.1%, ABR 37.3% mSEP 60.3%, tSEP 58.6%.BSRs were impaired in 90% of patients specifically with the following percentage frequency: VEMP 38.3%, TCR 3.4%, VMR 81.6% and AMR 83.3%. Brain RM revealed 71.7% of patients with BS lesion. Abnormalities of m EPs significatly correleted with:impaired BSRs (r=0.42e P= 0.008), BS MRI lesion burden (r=0.335 e p= 0.009 and EDSS score ( r=0.472 e P= 0.0001). BSR alterations significatly correleted with BS lesion burden (r=0.335 e p=0.009) and EDSS score (r=0.352 e p=0.006). No correlation were found between desease duration and the above mentioned variables. Concluison: Comparising BSR data with EP findings, MRI lesion burden and EDSS score it emerges that BSR recording may represent a useful, additional tool in providing evidence of BS dysfunction in MS with high sensitivity compared to the conventional praclinicla tests.
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|Titolo:||Exploring Brainstem functions in MS patients by combining neurophysiological and neuroradiological approaches|
|Data di pubblicazione:||2012|
|Appare nelle tipologie:||4.1 Contributo in Atti di convegno|