Objective: To exame sensitivity of brainbstem relflex (BSRs) and to correlate BSRs with multimodal evoked potentials (m EPs) and brain MRI lesion burden in relapsing-remitting multiple sclerosis patrient (RRMS). Methods: sixty RRMS patients ( age 33.3+/- 8.3, range 20-50, desease duration 8.2+/- 6.4 yrs, EDSS score 1.8+/-1.1) Underwent visual, acoustic, upper and lower somatosensory EP recordings (rispectively VEP, ABR, median SEP-mSEP and tibial SEP-tSEP9 and brain MRI. BSRs of interest were. the vestibulo-collic (VCR), trigemino-cervical (TCR), vestibulomasseteric (VMR) and acoustic- masseteric (AMR) reflexes. Neurological examination was rated according to the EDSS scale, mPE, BSRs, brain MRI and EDSS data wer quantified according to a conventional score. Results: EP abnormalities were recorded in 84.5% of patients distributed as follows: VEP 43.1%, ABR 37.3% mSEP 60.3%, tSEP 58.6%.BSRs were impaired in 90% of patients specifically with the following percentage frequency: VEMP 38.3%, TCR 3.4%, VMR 81.6% and AMR 83.3%. Brain RM revealed 71.7% of patients with BS lesion. Abnormalities of m EPs significatly correleted with:impaired BSRs (r=0.42e P= 0.008), BS MRI lesion burden (r=0.335 e p= 0.009 and EDSS score ( r=0.472 e P= 0.0001). BSR alterations significatly correleted with BS lesion burden (r=0.335 e p=0.009) and EDSS score (r=0.352 e p=0.006). No correlation were found between desease duration and the above mentioned variables. Concluison: Comparising BSR data with EP findings, MRI lesion burden and EDSS score it emerges that BSR recording may represent a useful, additional tool in providing evidence of BS dysfunction in MS with high sensitivity compared to the conventional praclinicla tests.

Exploring Brainstem functions in MS patients by combining neurophysiological and neuroradiological approaches / Magnano I.; Cabboi M.P.; Pilurzi G.; Conti M.; Achene A.; Salis A.; Pes G.; Ginatempo F.; Deriu F. - (2012), pp. 129-129. ((Intervento presentato al convegno 57° congresso nazionale società italiana di Neurofisiologia clinica tenutosi a Mantova nel 16-19 Maggio.

Exploring Brainstem functions in MS patients by combining neurophysiological and neuroradiological approaches

CONTI, Maurizio;PES, Giovanni Mario;Ginatempo F.;DERIU, Franca
2012

Abstract

Objective: To exame sensitivity of brainbstem relflex (BSRs) and to correlate BSRs with multimodal evoked potentials (m EPs) and brain MRI lesion burden in relapsing-remitting multiple sclerosis patrient (RRMS). Methods: sixty RRMS patients ( age 33.3+/- 8.3, range 20-50, desease duration 8.2+/- 6.4 yrs, EDSS score 1.8+/-1.1) Underwent visual, acoustic, upper and lower somatosensory EP recordings (rispectively VEP, ABR, median SEP-mSEP and tibial SEP-tSEP9 and brain MRI. BSRs of interest were. the vestibulo-collic (VCR), trigemino-cervical (TCR), vestibulomasseteric (VMR) and acoustic- masseteric (AMR) reflexes. Neurological examination was rated according to the EDSS scale, mPE, BSRs, brain MRI and EDSS data wer quantified according to a conventional score. Results: EP abnormalities were recorded in 84.5% of patients distributed as follows: VEP 43.1%, ABR 37.3% mSEP 60.3%, tSEP 58.6%.BSRs were impaired in 90% of patients specifically with the following percentage frequency: VEMP 38.3%, TCR 3.4%, VMR 81.6% and AMR 83.3%. Brain RM revealed 71.7% of patients with BS lesion. Abnormalities of m EPs significatly correleted with:impaired BSRs (r=0.42e P= 0.008), BS MRI lesion burden (r=0.335 e p= 0.009 and EDSS score ( r=0.472 e P= 0.0001). BSR alterations significatly correleted with BS lesion burden (r=0.335 e p=0.009) and EDSS score (r=0.352 e p=0.006). No correlation were found between desease duration and the above mentioned variables. Concluison: Comparising BSR data with EP findings, MRI lesion burden and EDSS score it emerges that BSR recording may represent a useful, additional tool in providing evidence of BS dysfunction in MS with high sensitivity compared to the conventional praclinicla tests.
Exploring Brainstem functions in MS patients by combining neurophysiological and neuroradiological approaches / Magnano I.; Cabboi M.P.; Pilurzi G.; Conti M.; Achene A.; Salis A.; Pes G.; Ginatempo F.; Deriu F. - (2012), pp. 129-129. ((Intervento presentato al convegno 57° congresso nazionale società italiana di Neurofisiologia clinica tenutosi a Mantova nel 16-19 Maggio.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11388/70970
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