Two peptide sequences from Park9 Parkinson’s disease gene, P1D2E3K4H5E6L7 (1) and F1C2G3D4G5A6N7D8C9G10 (2) have been studied in their interaction with Mn(II) and Zn(II) ions. These fragments lie from residue 1165 to 1171 and from 1184 to 1193 in the Park9 encoded protein, that can protect cells from manganese poisoning, an environmental risk factor for a Parkinson’s disease-like syndrome called Manganism. The study was carried out through potentiometric and spectroscopic (UV-Vis, EPR, mono- and multidimensional NMR) techniques, to cast light on the details of metal binding at different pH values and different ligand to metal molar ratios.
Park9 interaction with Manganese and other divalent cations / Zoroddu, Maria Antonietta; Remelli, M; Peana, Massimiliano Francesco; Medici, Serenella; Solinas, Costantino. - (2013), pp. 169-173. (Intervento presentato al convegno 12th International Symposium on Metal Ions in Biology and Medicine tenutosi a Punta del Este, Uruguay nel March 11-13, 2013).
Park9 interaction with Manganese and other divalent cations
ZORODDU, Maria Antonietta;PEANA, Massimiliano Francesco;MEDICI, Serenella;SOLINAS, Costantino
2013-01-01
Abstract
Two peptide sequences from Park9 Parkinson’s disease gene, P1D2E3K4H5E6L7 (1) and F1C2G3D4G5A6N7D8C9G10 (2) have been studied in their interaction with Mn(II) and Zn(II) ions. These fragments lie from residue 1165 to 1171 and from 1184 to 1193 in the Park9 encoded protein, that can protect cells from manganese poisoning, an environmental risk factor for a Parkinson’s disease-like syndrome called Manganism. The study was carried out through potentiometric and spectroscopic (UV-Vis, EPR, mono- and multidimensional NMR) techniques, to cast light on the details of metal binding at different pH values and different ligand to metal molar ratios.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
