Sulfonamides are an important class of compounds with a broad array of biological and pharmacological activities [1]. Drugs containing a sulfonamide moiety have wide-ranging applications in many areas of clinical medicine, as they act as effective antibacterials, diuretics, anticonvulsants, hypoglycemics and HIV protease inhibitors [2]. Recently, sulfonamides have been shown to be potent carbonic anhydrase [3], matrix metalloproteinase [4] and 11β-hydroxysteroid dehydrogenase type 1 inhibitors [5].The preparation of sulfonamides is normally achieved by reacting an amine with a substituted sulfonyl chloride or anhydride where a buffering base in an aprotic solvent is present .

Microwave-assisted synthesis of sulfonamides / Porcheddu, Andrea; DE LUCA, Lidia Vera Giovanna. - (2014), pp. 120-133. [10.4155/FSEB2013.13.51]

Microwave-assisted synthesis of sulfonamides

PORCHEDDU, Andrea;DE LUCA, Lidia Vera Giovanna
2014-01-01

Abstract

Sulfonamides are an important class of compounds with a broad array of biological and pharmacological activities [1]. Drugs containing a sulfonamide moiety have wide-ranging applications in many areas of clinical medicine, as they act as effective antibacterials, diuretics, anticonvulsants, hypoglycemics and HIV protease inhibitors [2]. Recently, sulfonamides have been shown to be potent carbonic anhydrase [3], matrix metalloproteinase [4] and 11β-hydroxysteroid dehydrogenase type 1 inhibitors [5].The preparation of sulfonamides is normally achieved by reacting an amine with a substituted sulfonyl chloride or anhydride where a buffering base in an aprotic solvent is present .
2014
978-1-910419-29-8
Microwave-assisted synthesis of sulfonamides / Porcheddu, Andrea; DE LUCA, Lidia Vera Giovanna. - (2014), pp. 120-133. [10.4155/FSEB2013.13.51]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11388/64250
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