A colonic drug delivery system is required to protect a drug during its transit through the upper gastro-intestinal tract and allow its release in the colon. The aim of this study was the preparation of dry-coated tablets designed for colonic release of the model drug Diclofenac sodium (DS). The system consists of a drug-pectine (PC) mixture as the core and hydroxypropylmethylcellulose (HPMC) alone or mixed in different ratios with poly(ε-caprolactone) (CL) as the coat layer.
Design and evaluation of dry-coated tablets for colonic delivery of diclofenac sodium / Gavini, Elisabetta; Rassu, Giovanna; Giunchedi, Paolo; Sanna, Vanna Annunziata; Pirisino, Gerolamo Antonio. - (2006). (Intervento presentato al convegno SardiniaChem 2006: giornata di studio dedicata alla chimica organica delle molecole biologicamente attive).
Design and evaluation of dry-coated tablets for colonic delivery of diclofenac sodium
Gavini, Elisabetta;Rassu, Giovanna;Giunchedi, Paolo;Sanna, Vanna Annunziata;Pirisino, Gerolamo Antonio
2006-01-01
Abstract
A colonic drug delivery system is required to protect a drug during its transit through the upper gastro-intestinal tract and allow its release in the colon. The aim of this study was the preparation of dry-coated tablets designed for colonic release of the model drug Diclofenac sodium (DS). The system consists of a drug-pectine (PC) mixture as the core and hydroxypropylmethylcellulose (HPMC) alone or mixed in different ratios with poly(ε-caprolactone) (CL) as the coat layer.| File | Dimensione | Formato | |
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