Diphenhydramine hydrochloride (DPH) is a histamine H1-receptor antagonist, widely used as antiallergic, antiemetic and antitussive drug in many pharmaceutical preparations. The aim of this study was to evaluate the vehicle effect on in vitro diffusion of DPH from new five topical formulations: microemulsion, microemulsion+silica, Na Alginate emulgel, Carbopol cream and hydroxyethylcellulose gel.
Evaluation of the vehicle effect on release of diphenhydramine hydrochloride from topical formulations: in vitro and in vivo preliminary studies / Peana, Alessandra Tiziana; Sanna, Vanna Annunziata; Moretti, Mario Domenico Luigi. - (2008). (Intervento presentato al convegno SardiniaChem 2008: giornata di studio dedicata alla chimica organica delle molecole biologicamente attive).
Evaluation of the vehicle effect on release of diphenhydramine hydrochloride from topical formulations: in vitro and in vivo preliminary studies
Peana, Alessandra Tiziana;Sanna, Vanna Annunziata;Moretti, Mario Domenico Luigi
2008-01-01
Abstract
Diphenhydramine hydrochloride (DPH) is a histamine H1-receptor antagonist, widely used as antiallergic, antiemetic and antitussive drug in many pharmaceutical preparations. The aim of this study was to evaluate the vehicle effect on in vitro diffusion of DPH from new five topical formulations: microemulsion, microemulsion+silica, Na Alginate emulgel, Carbopol cream and hydroxyethylcellulose gel.| File | Dimensione | Formato | |
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