Scrapie, a fatal neurodegenerative disorder of sheep, is characterized by deposition of an abnormal isoform of prion protein (PrPSc) in the central nervous system (CNS) and within the lymphoreticular system (LRS). Recent studies in mice transgenically engineered to develop organ specific inflammation demonstrated the cooccurrence of PrPScin the inflamed organs (kidney, pancreas and liver).
PrPScdeposition in mammary gland of sheep experimentally coinfected with scrapie and Maedi-Visna virus / Cancedda, Giovanna Maria; Saba, Mariangela; Carcassola, Gabriella; Demontis, Franca; Zucca, Rosalba; Santucciu, Cinzia; Maestrale, Caterina; Madau, Laura; Aguzzi, Adriano; Sigurdson, J. Chistina; Uras, Patrizia; Demurtas, Giulia; Ligios, Ciriaco. - In: ATTI ... CONVEGNO NAZIONALE AIPVET. - ISSN 1825-2265. - (2006), p. 28. (Intervento presentato al convegno 3. Congresso nazionale A.I.P.Vet.: atti).
PrPScdeposition in mammary gland of sheep experimentally coinfected with scrapie and Maedi-Visna virus
Ligios, Ciriaco
2006-01-01
Abstract
Scrapie, a fatal neurodegenerative disorder of sheep, is characterized by deposition of an abnormal isoform of prion protein (PrPSc) in the central nervous system (CNS) and within the lymphoreticular system (LRS). Recent studies in mice transgenically engineered to develop organ specific inflammation demonstrated the cooccurrence of PrPScin the inflamed organs (kidney, pancreas and liver).| File | Dimensione | Formato | |
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