Solid lipid nanoparticles (SLN) are considered as innovative drug carrier for topical application. The small size of the lipid particles ensures close contact to the stratum corneum and can increase the amount of the drug penetrating into the skin and it allows controlled drug release. The aim of this study was to develop controlled release gels containing SLN dispersions loaded with Econazole Nitrate (ECN) and to evaluateex vivoskin penetration of the drug released from the particles.
Ex vivocutaneous penetration of econazole nitrate from SLN incorporated in hydrophilic gels / Gavini, Elisabetta; Rassu, Giovanna; Giunchedi, Paolo; Canu, Giacomina; Sanna, Vanna Annunziata; Cossu, Massimo. - (2006). (Intervento presentato al convegno SardiniaChem 2006: giornata di studio dedicata alla chimica organica delle molecole biologicamente attive).
Ex vivocutaneous penetration of econazole nitrate from SLN incorporated in hydrophilic gels
Gavini, Elisabetta;Rassu, Giovanna;Giunchedi, Paolo;Sanna, Vanna Annunziata;Cossu, Massimo
2006-01-01
Abstract
Solid lipid nanoparticles (SLN) are considered as innovative drug carrier for topical application. The small size of the lipid particles ensures close contact to the stratum corneum and can increase the amount of the drug penetrating into the skin and it allows controlled drug release. The aim of this study was to develop controlled release gels containing SLN dispersions loaded with Econazole Nitrate (ECN) and to evaluateex vivoskin penetration of the drug released from the particles.| File | Dimensione | Formato | |
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