Pancreatic cancer (PaCa) is a multifaceted disorder with an extremely poor prognosis. There is an urgent need to identify new and safe drugs as well as to develop novel tumor-targeted controlled release systems for effective treatment of late stage and resistant PaCa. Active targeting via the inclusion of specific ligands on the nanoparticles (NPs) is envisioned to provide a powerful therapeutic strategy.Herein, we present a study on the design and the development of novel DFCencapsulated biocompatible polymeric NPs, functionalized with peptides to selectively bind to Plec-1 (PTP), or densely decorated by low molecular weight organic molecules as alternative targeting ligands (2-ABA), and evaluated a) the impact on ligand binding and b) thein vitroantiproliferative efficacy against a panel of PaCa cells.
Targeted nanoparticles for the delivery of novel bioactive molecules to pancreatic cancer cells / Sechi, Mario; Sanna, Vanna Annunziata; Pala, Nicolino; Marceddu, Salvatore; Pathani, Divya; Nurra, Salvatore; Nearnati, Nouri. - (2013). (Intervento presentato al convegno 35. Convegno della Divisione di chimica organica della Società Chimica Italiana).
Targeted nanoparticles for the delivery of novel bioactive molecules to pancreatic cancer cells
Sechi, Mario;Sanna, Vanna Annunziata;Pala, Nicolino;Nurra, Salvatore;
2013-01-01
Abstract
Pancreatic cancer (PaCa) is a multifaceted disorder with an extremely poor prognosis. There is an urgent need to identify new and safe drugs as well as to develop novel tumor-targeted controlled release systems for effective treatment of late stage and resistant PaCa. Active targeting via the inclusion of specific ligands on the nanoparticles (NPs) is envisioned to provide a powerful therapeutic strategy.Herein, we present a study on the design and the development of novel DFCencapsulated biocompatible polymeric NPs, functionalized with peptides to selectively bind to Plec-1 (PTP), or densely decorated by low molecular weight organic molecules as alternative targeting ligands (2-ABA), and evaluated a) the impact on ligand binding and b) thein vitroantiproliferative efficacy against a panel of PaCa cells.File | Dimensione | Formato | |
---|---|---|---|
Sanna_V_Targeted_nanoparticles_for_delivery.pdf
accesso aperto
Tipologia:
Versione editoriale (versione finale pubblicata)
Licenza:
Non specificato
Dimensione
788 kB
Formato
Adobe PDF
|
788 kB | Adobe PDF | Visualizza/Apri |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.