Pancreatic cancer (PaCa) is a multifaceted disorder with an extremely poor prognosis. There is an urgent need to identify new and safe drugs as well as to develop novel tumor-targeted controlled release systems for effective treatment of late stage and resistant PaCa. Active targeting via the inclusion of specific ligands on the nanoparticles (NPs) is envisioned to provide a powerful therapeutic strategy.Herein, we present a study on the design and the development of novel DFCencapsulated biocompatible polymeric NPs, functionalized with peptides to selectively bind to Plec-1 (PTP), or densely decorated by low molecular weight organic molecules as alternative targeting ligands (2-ABA), and evaluated a) the impact on ligand binding and b) thein vitroantiproliferative efficacy against a panel of PaCa cells.

Targeted nanoparticles for the delivery of novel bioactive molecules to pancreatic cancer cells / Sechi, Mario. - (2013). ((Intervento presentato al convegno 35. Convegno della Divisione di chimica organica della Società Chimica Italiana.

Targeted nanoparticles for the delivery of novel bioactive molecules to pancreatic cancer cells

Sechi, Mario;Sanna, Vanna Annunziata;Pala, Nicolino;Nurra, Salvatore;
2013

Abstract

Pancreatic cancer (PaCa) is a multifaceted disorder with an extremely poor prognosis. There is an urgent need to identify new and safe drugs as well as to develop novel tumor-targeted controlled release systems for effective treatment of late stage and resistant PaCa. Active targeting via the inclusion of specific ligands on the nanoparticles (NPs) is envisioned to provide a powerful therapeutic strategy.Herein, we present a study on the design and the development of novel DFCencapsulated biocompatible polymeric NPs, functionalized with peptides to selectively bind to Plec-1 (PTP), or densely decorated by low molecular weight organic molecules as alternative targeting ligands (2-ABA), and evaluated a) the impact on ligand binding and b) thein vitroantiproliferative efficacy against a panel of PaCa cells.
Targeted nanoparticles for the delivery of novel bioactive molecules to pancreatic cancer cells / Sechi, Mario. - (2013). ((Intervento presentato al convegno 35. Convegno della Divisione di chimica organica della Società Chimica Italiana.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11388/263640
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