Different methodologies are being developed, such as imaging, spectroscopy and electrochemistry, to study neurochemical dynamics in cell cultures or in intact brain [1-2]. One of these techniques involves the in-situ detection of biologically active molecules, including nitric oxide (NO) [3], glucose [4], glutamate (GLUT) [5-6] and lactate [1,7], in brain extracellular fluid (ECF), using implanted microsensors and biosensors. NO is a water-soluble free radical that readily diffuses through membranes and its actions in the CNS are largely studied.
Selective and sensitive poly-ortho-phenylenediamine-shielded microsensore and biosensors for in vivo neurochemical monitoring / Serra, Pier Andrea; Desole, Maria Speranza; Migheli, Rossana; Lowry, John P.; O'Neill, Robert D.; Rocchitta, Gaia Giovanna Maria. - (2008). (Intervento presentato al convegno SardiniaChem 2008: giornata di studio dedicata alla chimica organica delle molecole biologicamente attive).
Selective and sensitive poly-ortho-phenylenediamine-shielded microsensore and biosensors for in vivo neurochemical monitoring
Serra, Pier Andrea;Desole, Maria Speranza;Migheli, Rossana;Rocchitta, Gaia Giovanna Maria
2008-01-01
Abstract
Different methodologies are being developed, such as imaging, spectroscopy and electrochemistry, to study neurochemical dynamics in cell cultures or in intact brain [1-2]. One of these techniques involves the in-situ detection of biologically active molecules, including nitric oxide (NO) [3], glucose [4], glutamate (GLUT) [5-6] and lactate [1,7], in brain extracellular fluid (ECF), using implanted microsensors and biosensors. NO is a water-soluble free radical that readily diffuses through membranes and its actions in the CNS are largely studied.File | Dimensione | Formato | |
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