The Carbonic Anhydrases (CAs) are a family of zinc enzymes deputed to the interconversion of carbonic dioxide to hydrogen carbonate. Herein, we report on a sustainable modular strategy, also called "clicktail approach", used to obtain two series of 4-(4-substituted-lH-l,2,3-triazol-lyl) benzenesulfonamides. Design and synthesis strategies, x-ray derived CA-ligand binding mode and enzyme-based inhibition results will be presented.
The "Click-tail approach" for the design and synthesis of novel carbonic anhydrase inhibitors / Sechi, Mario; Pala, Nicolino; Micheletto, Laura; Ihm, Simone; Mckenna, Robert; Supuran, Claudiu T.; Carta, Fabrizio. - (2013), pp. 20-20. (Intervento presentato al convegno La parola ai giovani: 12. [Convegno]: abstract book).
The "Click-tail approach" for the design and synthesis of novel carbonic anhydrase inhibitors
Sechi, Mario;Pala, Nicolino;
2013-01-01
Abstract
The Carbonic Anhydrases (CAs) are a family of zinc enzymes deputed to the interconversion of carbonic dioxide to hydrogen carbonate. Herein, we report on a sustainable modular strategy, also called "clicktail approach", used to obtain two series of 4-(4-substituted-lH-l,2,3-triazol-lyl) benzenesulfonamides. Design and synthesis strategies, x-ray derived CA-ligand binding mode and enzyme-based inhibition results will be presented.| File | Dimensione | Formato | |
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