HIV-1 integrase (IN) mediates the insertion of viral cDNA into the cell genome, a vital process for replication. This step is catalyzed by two separate DNA reaction events, termed 3’-processing (3’-P) and strand transfer (ST). The second step, ST, is the concerted transesterification reaction that results in the insertion of this DNA product within the host genome. Using this in vitro method we present here the activity of six small molecule IN inhibitors.
Single amino acid substitution in HIV-1 integrase catalytic core causes a dramatic shift in inhibitor selectivity / Sechi, Mario; Al-Mawsawi, Laith Q.; Neamati, Nouri. - (2008). (Intervento presentato al convegno SardiniaChem 2008: giornata di studio dedicata alla chimica organica delle molecole biologicamente attive).
Single amino acid substitution in HIV-1 integrase catalytic core causes a dramatic shift in inhibitor selectivity
Sechi, Mario;
2008-01-01
Abstract
HIV-1 integrase (IN) mediates the insertion of viral cDNA into the cell genome, a vital process for replication. This step is catalyzed by two separate DNA reaction events, termed 3’-processing (3’-P) and strand transfer (ST). The second step, ST, is the concerted transesterification reaction that results in the insertion of this DNA product within the host genome. Using this in vitro method we present here the activity of six small molecule IN inhibitors.| File | Dimensione | Formato | |
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