Resveratrol-loaded nanoparticles based on polymeric blend for prostsate cancer treatment

The trans-resveratrol (RSV) has been reported to act as an antiproliferative and chemopreventive agent against a wide variety of tumors, including prostate cancer (PCa)I,2. Nanoencapsulation of RSV represents a powerful strategy to provide protection of degradation, enhancement of bioavailability, improvement of intracellular penetration and control delivery,4.We developed novel polymeric nanoparticles (NPs) encapsulating RSV (nano-RSV), based on a polymeric blend, as effective prototypes for PCa treatment. Our results support the potential use of these prototypes for the controlled delivery ofRSV for PCa treatment.