3-Alkylidene-2-oxindoles represent a simple, yet enabling subfamily of indole alkaloids, and their ability to react as electron-poor acceptors has largely been investigated. In contrast, their utility as pronucleophilic synthons remains elusive. In this context, the present describes the successful execution of the direct, organocatalytic asymmetric Michael addition of prochiral 3-alkylideneoxindoles to nitroolefins.
Direct vinylogous Michael addition of prochiral 3-alkylideneoxindoles to nitroolefins / Pinna, Luigi; Zambrano, Vincenzo; Curti, Claudio; Casiraghi, Giovanni; Rassu, Gloria Maria Rita. - (2013). (Intervento presentato al convegno 35. Convegno della Divisione di chimica organica della Società Chimica Italiana).
Direct vinylogous Michael addition of prochiral 3-alkylideneoxindoles to nitroolefins
Pinna, Luigi;
2013-01-01
Abstract
3-Alkylidene-2-oxindoles represent a simple, yet enabling subfamily of indole alkaloids, and their ability to react as electron-poor acceptors has largely been investigated. In contrast, their utility as pronucleophilic synthons remains elusive. In this context, the present describes the successful execution of the direct, organocatalytic asymmetric Michael addition of prochiral 3-alkylideneoxindoles to nitroolefins.| File | Dimensione | Formato | |
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