A large-scale computational model of the cerebellum granular layer has been adapted to generate long-term synaptic plasticity in response to afferent mossy fiber bursts. A simple learning rule was elaborated in order to link the average granule cell depolarization to LTP and LTD. Briefly, LTP was generated for membrane potentials >-40 mV and LTD for membrane potentials <-40 mV. The result was to generate LTP and stronger excitation in the core of active clusters, which were surrounded by LTD. These changes were accompanied by a faster and stronger spike generation compared to the surround. These results reproduce the experimental observations and provide a valuable and efficient tool for implementing autonomous learning algorithms in the cerebellar neuronal network.

Realistic Modeling of Large-Scale Networks: Spatio-temporal Dynamics and Long-Term Synaptic Plasticity in the Cerebellum / D'Angelo, E; Solinas, S. - 6691:(2011), pp. 547-553. ((Intervento presentato al convegno Advances in Computational Intelligence - 11th International Work-Conference on Artificial Neural Networks, IWANN 2011 [10.1007/978-3-642-21501-8_68].

Realistic Modeling of Large-Scale Networks: Spatio-temporal Dynamics and Long-Term Synaptic Plasticity in the Cerebellum

Solinas, S
Investigation
2011

Abstract

A large-scale computational model of the cerebellum granular layer has been adapted to generate long-term synaptic plasticity in response to afferent mossy fiber bursts. A simple learning rule was elaborated in order to link the average granule cell depolarization to LTP and LTD. Briefly, LTP was generated for membrane potentials >-40 mV and LTD for membrane potentials <-40 mV. The result was to generate LTP and stronger excitation in the core of active clusters, which were surrounded by LTD. These changes were accompanied by a faster and stronger spike generation compared to the surround. These results reproduce the experimental observations and provide a valuable and efficient tool for implementing autonomous learning algorithms in the cerebellar neuronal network.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11388/248703
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