This invention is in the field of medicinal chemistry. In particular, the invention relates to a new classe of small molecules having a quinazolinedione structure with function as reactive oxygen species (ROS) inducers and inhibitors of mitochondrial activity within cancer cells (e.g. pancreatic cancer cells), and their use as therapeutics for the treatment of cancer (e.g. pancreatic cancer) and other diseases.
SMALL MOLECULES INDUCERS OFREACTIVE OXYGEN SPECIES AND INHIBITORS OF MITOCHONDRIAL ACTIVITY / Neamati, Nouri; Sechi, Mario. - (2017).