"To determine the minimum alveolar concentration (MAC) of sevoflurane in mechanically ventilated sheep.. Prospective study. Fourteen healthy adult female Sardinian bred sheep were selected. Anaesthesia was. induced with sevoflurane delivered in oxygen (3 l\/min) through a mask with the vaporizer set at 8%. An. endotracheal tube was inserted, and a probe for continuous measurement of end‐tidal and inspired. sevoflurane concentrations was placed in the trachea via the endotracheal tube. After 30 minutes of. equilibration at an end‐tidal sevoflurane concentration of 2,8%, an electrical stimulus [5Hz \/1 msec. (impulse duration) \/ 50.0 mA] was applied to the skin of the lateral side of the right antebrachium for one. minute or until a gross purposeful movement response was obtained. The vaporizer dial setting was. changed in order to obtain an increase or decrease by 0,1‐ 0,2% in end‐tidal sevoflurane concentration,. dependent upon whether a motor response had been elicited by noxious (electrical) stimulation or not.. Following a 10‐minute equilibration period the noxious stimulation was repeated. The MAC was defined as. the mean of the lowest end‐tidal sevoflurane concentration that prevented a positive motor response and. the highest concentration that allowed a positive motor response and determined always twice. Time to. induction of anaesthesia, time to extubation and time for recovery (i.e. time to standing up) were also. recorded.. The mean± SD of the MAC of sevoflurane was 2,6±0,3%. Time to intubation was 223±106 seconds, time to. extubation was 351±121 seconds and time to recovery was 780±282 seconds.. Sevoflurane administration in sheep allows for a smooth induction of anaesthesia and fast extubation and. smooth recovery from anaesthesia. The MAC of sevoflurane measured in sheep was slightly higher than. that reported in other species (e.g. goat and llamas)."
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|Titolo:||Determination of Minimum Alveolar Concentration (MAC) of sevoflurane in mechanically ventilated sheep|
|Data di pubblicazione:||2013|
|Appare nelle tipologie:||4.1 Contributo in Atti di convegno|