Levels of uric acid, xanthine, hypoxanthine, ascorbic acid (AA), dehydroascorbic acid, glutathione (GSH), noradrenaline (NA), dopamine (DA), dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA) and and 3-methoxytyramine were determined in the striatum and/or in the brainstem of 3-month-old male Wistar rats given manganese (MnCl2, 200 mg/kg/day for 7 days by gavage) alone or associated with allopurinol. Allopurinol alone (300 mg/kg/day for 4 days by gavage) decreased uric acid and increased xanthine levels both in the striatum and in the brainstem; moreover, allopurinol decreased the striatal DOPAC + HVA/DA ratio. Allopurinol antagonised the Mn-induced: (a) increase in the DOPAC + HVA/DA ratio; (b) increase in uric acid levels and AA oxidation; and (c) decrease in GSH and NA levels. We conclude that allopurinol may protect against Mn-induced oxidative stress by inhibiting both DA oxidative metabolism and xanthine oxidase-mediated formation of reactive oxygen species.

Allopurinol protects against manganese-induced oxidative stress in the striatum and in the brainstem of the rat / Desole, Maria Speranza; Esposito, G; Migheli, Rossana; Fresu, L; Sircana, S; Miele, M; De Natale, G; Miele, E.. - In: NEUROSCIENCE LETTERS. - ISSN 0304-3940. - 192:2(1995), pp. 73-76.

Allopurinol protects against manganese-induced oxidative stress in the striatum and in the brainstem of the rat.

DESOLE, Maria Speranza;MIGHELI, Rossana;
1995-01-01

Abstract

Levels of uric acid, xanthine, hypoxanthine, ascorbic acid (AA), dehydroascorbic acid, glutathione (GSH), noradrenaline (NA), dopamine (DA), dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA) and and 3-methoxytyramine were determined in the striatum and/or in the brainstem of 3-month-old male Wistar rats given manganese (MnCl2, 200 mg/kg/day for 7 days by gavage) alone or associated with allopurinol. Allopurinol alone (300 mg/kg/day for 4 days by gavage) decreased uric acid and increased xanthine levels both in the striatum and in the brainstem; moreover, allopurinol decreased the striatal DOPAC + HVA/DA ratio. Allopurinol antagonised the Mn-induced: (a) increase in the DOPAC + HVA/DA ratio; (b) increase in uric acid levels and AA oxidation; and (c) decrease in GSH and NA levels. We conclude that allopurinol may protect against Mn-induced oxidative stress by inhibiting both DA oxidative metabolism and xanthine oxidase-mediated formation of reactive oxygen species.
1995
Allopurinol protects against manganese-induced oxidative stress in the striatum and in the brainstem of the rat / Desole, Maria Speranza; Esposito, G; Migheli, Rossana; Fresu, L; Sircana, S; Miele, M; De Natale, G; Miele, E.. - In: NEUROSCIENCE LETTERS. - ISSN 0304-3940. - 192:2(1995), pp. 73-76.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11388/81032
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