Reactivities of human sera against selected recombinant Mycobacterium tuberculosis antigens were assessed by enzyme-linked immunosorbent assay. The results obtained indicate that patients with tuberculosis (TB) do not develop a strong humoral response against PE_PGRS and PPE proteins or against the Ag85B and heparin-binding hemagglutinin (HBHA) recombinant antigens. Conversely, purified methylated HBHA was strongly recognized by sera obtained from TB patients compared to controls.
Patients with pulmonary tuberculosis develop a strong humoral response against methylated heparin-binding hemagglutinin / Zanetti, Stefania Anna Lucia; Bua, Alessandra; Delogu, G; Pusceddu, C; Mura, M; Saba, F; Pirina, Pietro; Garzelli, C; Vertuccio, C; Sechi, Leonardo Antonio; Fadda, G.. - In: CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY. - ISSN 1071-412X. - 12:9(2005), pp. 1135-1138. [10.1128/CDLI.12.9.1135-1138.2005]
Patients with pulmonary tuberculosis develop a strong humoral response against methylated heparin-binding hemagglutinin
ZANETTI, Stefania Anna Lucia;BUA, Alessandra;PIRINA, Pietro;SECHI, Leonardo Antonio;
2005-01-01
Abstract
Reactivities of human sera against selected recombinant Mycobacterium tuberculosis antigens were assessed by enzyme-linked immunosorbent assay. The results obtained indicate that patients with tuberculosis (TB) do not develop a strong humoral response against PE_PGRS and PPE proteins or against the Ag85B and heparin-binding hemagglutinin (HBHA) recombinant antigens. Conversely, purified methylated HBHA was strongly recognized by sera obtained from TB patients compared to controls.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.