Copper(II) complexes of histamine modified 2'-deoxyriboadenosine (N-[(9-beta-D-2'-deoxyribofuranosylpurin-6-yl)-carbamoyl]histamine) ligand were studied by potentiometric, UV-visible and EPR techniques. The imidazole residue of the ligand was described as the main binding site forming mono-, bis-(ligand) and dimer complexes, but the interactions between adenosine nitrogen N(1) and carbamoyl nitrogen atoms and the copper(II) ion also were detected. This is the first report evaluating the coordinating ability of such a modified adenosine ligand towards copper(II) ion. Our findings suggest that histamine modified 2'-deoxyriboadenosine could chelate efficiently copper(II) ions if it were incorporated into DNAzyme sequence. (C) 2010 Elsevier Inc. All rights reserved.

Histamine modified 2 '-deoxyriboadenosine - Potential copper binding site in DNAzymes / Lodyga Chruscinska, E; Sochacka, E; Smuga, D; Chruscinski, L; Micera, Giovanni; Sanna, D; Turek, M; Gasiorkiewicz, M.. - In: JOURNAL OF INORGANIC BIOCHEMISTRY. - ISSN 0162-0134. - 104:5(2010), pp. 570-575. [10.1016/j.jinorgbio.2010.01.009]

Histamine modified 2 '-deoxyriboadenosine - Potential copper binding site in DNAzymes

MICERA, Giovanni;
2010-01-01

Abstract

Copper(II) complexes of histamine modified 2'-deoxyriboadenosine (N-[(9-beta-D-2'-deoxyribofuranosylpurin-6-yl)-carbamoyl]histamine) ligand were studied by potentiometric, UV-visible and EPR techniques. The imidazole residue of the ligand was described as the main binding site forming mono-, bis-(ligand) and dimer complexes, but the interactions between adenosine nitrogen N(1) and carbamoyl nitrogen atoms and the copper(II) ion also were detected. This is the first report evaluating the coordinating ability of such a modified adenosine ligand towards copper(II) ion. Our findings suggest that histamine modified 2'-deoxyriboadenosine could chelate efficiently copper(II) ions if it were incorporated into DNAzyme sequence. (C) 2010 Elsevier Inc. All rights reserved.
2010
Histamine modified 2 '-deoxyriboadenosine - Potential copper binding site in DNAzymes / Lodyga Chruscinska, E; Sochacka, E; Smuga, D; Chruscinski, L; Micera, Giovanni; Sanna, D; Turek, M; Gasiorkiewicz, M.. - In: JOURNAL OF INORGANIC BIOCHEMISTRY. - ISSN 0162-0134. - 104:5(2010), pp. 570-575. [10.1016/j.jinorgbio.2010.01.009]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11388/62782
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