Transient anoxia obtained in curarized rats by momentary stopping of the artificial respiration (80 sec duration) induced a failure of the cerebral electrical activity. This effect was characterized by cessation of the spontaneous unitary discharge of cortical neurons and reduction of amplitude of somatosensory evoked potentials. Pretreatment with flunarizine (10 mg/kg/os) or suloctidil (50 mg/kg/os) induced a distinct improvement of the resistance to anoxia and of the recovery of the cerebral electrical activity.
Protective effects of Ca++-antagonist agents on the cerebral electrical activity during anoxia in the rat / Tolu, Eusebio; Mameli, O; Caria, Ma; Melis, Francesco; Anania, Vittorio Domenico; Desole, Maria Speranza. - In: PHARMACOLOGICAL RESEARCH COMMUNICATIONS. - ISSN 0031-6989. - 15:9(1983), pp. 833-842.
Protective effects of Ca++-antagonist agents on the cerebral electrical activity during anoxia in the rat.
TOLU, Eusebio;Caria MA;MELIS, Francesco;ANANIA, Vittorio Domenico;DESOLE, Maria Speranza
1983-01-01
Abstract
Transient anoxia obtained in curarized rats by momentary stopping of the artificial respiration (80 sec duration) induced a failure of the cerebral electrical activity. This effect was characterized by cessation of the spontaneous unitary discharge of cortical neurons and reduction of amplitude of somatosensory evoked potentials. Pretreatment with flunarizine (10 mg/kg/os) or suloctidil (50 mg/kg/os) induced a distinct improvement of the resistance to anoxia and of the recovery of the cerebral electrical activity.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
