New tricyclic derivatives with cyclocondensed pyrido-pyrazine 7,10 and pyrido-diazepine 20a,20b skeletons were synthetized and biologically investigated. The compounds, preliminarily tested on explorative, muscle relaxing, antinociceptive, spontaneous motor activities and influence on the narcotic effect of Evipan, revealed interesting CNS depressant and analgesic activities. The pyrido[2,3-e]pyrrolo[1,2-a]pyrazine structure of 7 appeared the most promising for analgesic and neuroleptic activities. The above compounds were assayed also for their capacity to inhibit DNA synthesis in Ehrlich ascites tumor cells; 20a appeared to be able of inducing a significant inhibition.

Synthesis and CNS activities of pyridopyrazinones and pyridodiazepinones derivatives / F., Savelli; A., Boido; M., Satta; Peana, Alessandra Tiziana; C., Marzano. - In: IL FARMACO. - ISSN 0014-827X. - 49:4(1994), pp. 259-265.

Synthesis and CNS activities of pyridopyrazinones and pyridodiazepinones derivatives

PEANA, Alessandra Tiziana;
1994-01-01

Abstract

New tricyclic derivatives with cyclocondensed pyrido-pyrazine 7,10 and pyrido-diazepine 20a,20b skeletons were synthetized and biologically investigated. The compounds, preliminarily tested on explorative, muscle relaxing, antinociceptive, spontaneous motor activities and influence on the narcotic effect of Evipan, revealed interesting CNS depressant and analgesic activities. The pyrido[2,3-e]pyrrolo[1,2-a]pyrazine structure of 7 appeared the most promising for analgesic and neuroleptic activities. The above compounds were assayed also for their capacity to inhibit DNA synthesis in Ehrlich ascites tumor cells; 20a appeared to be able of inducing a significant inhibition.
1994
Synthesis and CNS activities of pyridopyrazinones and pyridodiazepinones derivatives / F., Savelli; A., Boido; M., Satta; Peana, Alessandra Tiziana; C., Marzano. - In: IL FARMACO. - ISSN 0014-827X. - 49:4(1994), pp. 259-265.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11388/58193
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