Background. The early detection of wearing-off in Parkinson disease (DEEP) observational study demonstrated that women with Parkinson’s disease (PD) carry an increased risk (80.1%) for wearing-off (WO). This post hoc analysis of DEEP study evaluates gender differences on WO and associated phenomena. Methods. Patients on dopaminergic treatment for ≥1 year were included in this multicenter observational cross-sectional study. In a single visit, WO was diagnosed based on neurologist assessment as well as the use of the 19-item wearing-off questionnaire (WOQ-19); WO was defined for scores ≥2. Post hoc analyses were conducted to investigate gender difference for demographic and clinical features with respect to WO. Results. Of 617 patients enrolled, 236 were women and 381 were men. Prevalence of WO was higher among women, according to both neurologists’ judgment (61.9% versus 53.8%, 𝑃 = 0.045)andtheWOQ-19analysis(72.5%versus64.0%,𝑃 = 0.034).InpatientswithWO(WOQ-19),womenexperienced ≥1 motor symptom in 72.5% versus 64.0% in men and ≥1 nonmotor symptom in 44.5% versus 36.7%, in men. Conclusions.Our results suggest WO as more common among women, for both motor and nonmotor symptoms. Prospective studies are warranted to investigate this potential gender-effect.

The "gender factor" in wearing-off among patients with Parkinson's disease: a post hoc analysis of DEEP study / Colombo, D; Abbruzzese, G; Antonini, A; Barone, P; Bellia, G; Franconi, Flavia; Simoni, L; Attar, M; Zagni, E; Haggiag, S; Stocchi, F.. - In: THE SCIENTIFIC WORLD JOURNAL. - ISSN 1537-744X. - 2015:(2015), p. 787451. [10.1155/2015/787451]

The "gender factor" in wearing-off among patients with Parkinson's disease: a post hoc analysis of DEEP study

FRANCONI, Flavia;
2015-01-01

Abstract

Background. The early detection of wearing-off in Parkinson disease (DEEP) observational study demonstrated that women with Parkinson’s disease (PD) carry an increased risk (80.1%) for wearing-off (WO). This post hoc analysis of DEEP study evaluates gender differences on WO and associated phenomena. Methods. Patients on dopaminergic treatment for ≥1 year were included in this multicenter observational cross-sectional study. In a single visit, WO was diagnosed based on neurologist assessment as well as the use of the 19-item wearing-off questionnaire (WOQ-19); WO was defined for scores ≥2. Post hoc analyses were conducted to investigate gender difference for demographic and clinical features with respect to WO. Results. Of 617 patients enrolled, 236 were women and 381 were men. Prevalence of WO was higher among women, according to both neurologists’ judgment (61.9% versus 53.8%, 𝑃 = 0.045)andtheWOQ-19analysis(72.5%versus64.0%,𝑃 = 0.034).InpatientswithWO(WOQ-19),womenexperienced ≥1 motor symptom in 72.5% versus 64.0% in men and ≥1 nonmotor symptom in 44.5% versus 36.7%, in men. Conclusions.Our results suggest WO as more common among women, for both motor and nonmotor symptoms. Prospective studies are warranted to investigate this potential gender-effect.
2015
The "gender factor" in wearing-off among patients with Parkinson's disease: a post hoc analysis of DEEP study / Colombo, D; Abbruzzese, G; Antonini, A; Barone, P; Bellia, G; Franconi, Flavia; Simoni, L; Attar, M; Zagni, E; Haggiag, S; Stocchi, F.. - In: THE SCIENTIFIC WORLD JOURNAL. - ISSN 1537-744X. - 2015:(2015), p. 787451. [10.1155/2015/787451]
File in questo prodotto:
File Dimensione Formato  
Colombo_D_Gender_factor_in_wearing-off.pdf

accesso aperto

Tipologia: Versione editoriale (versione finale pubblicata)
Licenza: Creative commons
Dimensione 1.24 MB
Formato Adobe PDF
1.24 MB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11388/46193
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact