Whole blood from Mycobacterium tuberculosis-infected subjects was stimulated with heparin-binding hemagglutinin (HBHA). Tuberculosis (TB) patients showed an HBHA-specific T-cell response characterized by low-IFN-γ/high-TNF-α secretion, while asymptomatic subjects with latent infection (LTBI) and TB patients under therapy showed a pattern with high IFN-γ/low TNF-α. These results underscore the usefulness of HBHA in helping to distinguish LTBI subjects versus TB patients.
Tuberculosis patients are characterized by a low-IFN-γ/high-TNF-γ response to methylated HBHA produced in M. smegmatis / Molicotti, Paola; Bua, Alessandra; Cubeddu, Marina; Cannas, Sara; Delogu, G; Zanetti, Stefania Anna Lucia. - In: DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE. - ISSN 0732-8893. - 71:4(2011), pp. 449-452. [10.1016/j.diagmicrobio.2011.08.010]
Tuberculosis patients are characterized by a low-IFN-γ/high-TNF-γ response to methylated HBHA produced in M. smegmatis
MOLICOTTI, Paola;BUA, Alessandra;CUBEDDU, Marina;CANNAS, Sara;ZANETTI, Stefania Anna Lucia
2011-01-01
Abstract
Whole blood from Mycobacterium tuberculosis-infected subjects was stimulated with heparin-binding hemagglutinin (HBHA). Tuberculosis (TB) patients showed an HBHA-specific T-cell response characterized by low-IFN-γ/high-TNF-α secretion, while asymptomatic subjects with latent infection (LTBI) and TB patients under therapy showed a pattern with high IFN-γ/low TNF-α. These results underscore the usefulness of HBHA in helping to distinguish LTBI subjects versus TB patients.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
