Findings in humans and animals have demonstrated a potential role for Mycobacterium avium subsp. paratuberculosis (MAP) antigenic components in encephalitogenic T cell activation. Here we reported that oral administration of MAP activates the mucosal immunity and exacerbates active experimental autoimmune encephalomyelitis (EAE) in C57BL/6J mice, modulating the immune cell traffic from secondary lymphoid organs to central nervous system. The detection of antigenic mycobacterial components by intestinal antigen-presenting cells may modulate the immune system and the subsequent inflammatory status through various signaling mechanisms, including the synthesis of pro-inflammatory cytokines involved in EAE pathogenesis.

A mucosal immune response induced by oral administration of heat-killed Mycobacterium avium subsp. paratuberculosis exacerbates EAE / Cossu, D.; Yokoyama, K.; Sakanishi, T.; Kuwahara-Arai, K.; Momotani, E.; Hattori, N.. - In: JOURNAL OF NEUROIMMUNOLOGY. - ISSN 0165-5728. - 352:(2021), p. 577477. [10.1016/j.jneuroim.2021.577477]

A mucosal immune response induced by oral administration of heat-killed Mycobacterium avium subsp. paratuberculosis exacerbates EAE

Cossu D.;
2021-01-01

Abstract

Findings in humans and animals have demonstrated a potential role for Mycobacterium avium subsp. paratuberculosis (MAP) antigenic components in encephalitogenic T cell activation. Here we reported that oral administration of MAP activates the mucosal immunity and exacerbates active experimental autoimmune encephalomyelitis (EAE) in C57BL/6J mice, modulating the immune cell traffic from secondary lymphoid organs to central nervous system. The detection of antigenic mycobacterial components by intestinal antigen-presenting cells may modulate the immune system and the subsequent inflammatory status through various signaling mechanisms, including the synthesis of pro-inflammatory cytokines involved in EAE pathogenesis.
2021
A mucosal immune response induced by oral administration of heat-killed Mycobacterium avium subsp. paratuberculosis exacerbates EAE / Cossu, D.; Yokoyama, K.; Sakanishi, T.; Kuwahara-Arai, K.; Momotani, E.; Hattori, N.. - In: JOURNAL OF NEUROIMMUNOLOGY. - ISSN 0165-5728. - 352:(2021), p. 577477. [10.1016/j.jneuroim.2021.577477]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11388/246059
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