The occurrence of high rates of somatic mutations in cancer is believed to correspond to increased frequency of neo-epitope formation and tumor immunogenicity. Thus, classification of patients with cancer according to degree a somatic hyper-mutational status could be proposed as a predictive biomarker of responsiveness to immunotherapy with immune checkpoint inhibitors. Here, we discuss the suitable and reliable tests easily adoptable in clinical practice to assess somatic mutational status in patients with advanced cancer.
Genetic instability and increased mutational load: Which diagnostic tool best direct patients with cancer to immunotherapy? / Palmieri, G.; Colombino, M.; Cossu, A.; Marchetti, A.; Botti, G.; Ascierto, P. A.. - In: JOURNAL OF TRANSLATIONAL MEDICINE. - ISSN 1479-5876. - 15:1(2017), p. 17. [10.1186/s12967-017-1119-6]
Genetic instability and increased mutational load: Which diagnostic tool best direct patients with cancer to immunotherapy?
Palmieri G.;Cossu A.;
2017-01-01
Abstract
The occurrence of high rates of somatic mutations in cancer is believed to correspond to increased frequency of neo-epitope formation and tumor immunogenicity. Thus, classification of patients with cancer according to degree a somatic hyper-mutational status could be proposed as a predictive biomarker of responsiveness to immunotherapy with immune checkpoint inhibitors. Here, we discuss the suitable and reliable tests easily adoptable in clinical practice to assess somatic mutational status in patients with advanced cancer.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
