Increased expression of the retroviruses of HERV-W family has been linked to multiple sclerosis (MS) pathophysiology; nothing is known at the moment about MOG-IgG associated disorders. We compared antibody response against HERV-W peptides among patients with MOG-IgG associated disorders, multiple sclerosis (MS) and aquaporin-4 (AQP4)-IgG positive neuromyelitis optica spectrum disorder (NMOSD). A total of 102 serum samples were retrospectively analyzed. Antibody reactivity against HERV-W env peptides was similar in MOG-IgG associated disorders and MS, but different from AQP4-IgG positive NMOSD. Our findings expand the diagnostic role of HERV-W antibodies to the spectrum of demyelinating disorders associated with MOG-IgG.
Antibody response against HERV-W in patients with MOG-IgG associated disorders, multiple sclerosis and NMOSD / Arru, G.; Sechi, E.; Mariotto, S.; Zarbo, I. R.; Ferrari, S.; Gajofatto, A.; Monaco, S.; Deiana, G. A.; Bo, M.; Sechi, L. A.; Sechi, G. P.. - In: JOURNAL OF NEUROIMMUNOLOGY. - ISSN 0165-5728. - 338:(2020), p. 577110. [10.1016/j.jneuroim.2019.577110]
Antibody response against HERV-W in patients with MOG-IgG associated disorders, multiple sclerosis and NMOSD
Arru G.;Sechi E.;Zarbo I. R.;Ferrari S.;Deiana G. A.;Bo M.;Sechi L. A.;Sechi G. P.
2020-01-01
Abstract
Increased expression of the retroviruses of HERV-W family has been linked to multiple sclerosis (MS) pathophysiology; nothing is known at the moment about MOG-IgG associated disorders. We compared antibody response against HERV-W peptides among patients with MOG-IgG associated disorders, multiple sclerosis (MS) and aquaporin-4 (AQP4)-IgG positive neuromyelitis optica spectrum disorder (NMOSD). A total of 102 serum samples were retrospectively analyzed. Antibody reactivity against HERV-W env peptides was similar in MOG-IgG associated disorders and MS, but different from AQP4-IgG positive NMOSD. Our findings expand the diagnostic role of HERV-W antibodies to the spectrum of demyelinating disorders associated with MOG-IgG.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
